By Jennifer I. Lim (ed.)
Addressing a huge affecting thousands all over the world, this resource compiles the main sensible and groundbreaking examine at the etiology, evaluation, and therapy of Age-Related Macular Degeneration (AMD). With full-color illustrations all through, this reference explores learn developments that experience led to novel treatments that provide sight saving, much less damaging different types of remedy for exudative AMD, in addition to techniques to avoid the development of non-exudative AMD. With 3 new chapters and expansive quantity of part updates, this resource offers the most recent stories on OCT imaging, experimental remedies, new purposes for thermal lasers, and gene remedy for AMD. The resource additionally summarizes reports from present medical trials to stay the greatest within the provision of take care of sufferers with this disabling disorder.
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Additional info for Age-Related Macular Degeneration
Infectious Etiology of Atherosclerosis Although numerous risk factors are associated with the initiation and progression of atherosclerosis, an infectious etiology has been suggested by recent data. Many patients with atherosclerosis exhibit signs of mild systemic inﬂammation, especially elevated serum C-reactive protein (CRP) and erythrocyte sedimentation rate (121). Statistical evidence has been generated to suggest that infection with various infectious agents, especially Chlamydia pneumoniae or cytomegalovirus (CMV), might initiate vascular injury and explain the systemic inﬂammatory signs (122–125).
10). CFH binds principally to C3b and accelerates the decay of the alternative pathway D3-convertase and participates as a cofactor for the factor-I–mediated proteolytic inactivation of C3b (190). Interestingly, it is the binding of CFH to sialic residues on the cell surface which is critical to its ability to inhibit C3b. CFH also binds to other multiple residues within various bacteria.
Typically occurring after invasive infection or iatrogenically administered drugs, this mechanism may be very important in glomerular diseases (102) and has been postulated to induce ocular inﬂammation (103,104). Physical size and charge of the antigen are important. For example, antigen trapping within the choriocapillaris may contribute to ocular histoplasmosis syndrome (OHS) (104). 19 EXAMPLES OF IMMUNE AND INFLAMMATORY MECHANISMS OF NONOCULAR DEGENERATIVE DISEASES Immune Mechanisms in Atherosclerosis Myocardial infarction due to thrombosis of atherosclerotic coronary arteries is the major cause of death in western countries, and epidemiologic studies suggest a possible association with AMD (105,106).
Age-Related Macular Degeneration by Jennifer I. Lim (ed.)