By Andreas Stahl
This ebook presents a concise evaluate over the pathology of retinal angiogenic illnesses and explains why anti-angiogenic remedy is valuable in such a lot of sufferers. The reader is guided throughout the a variety of medical symptoms for anti-angiogenic remedy and made conscious of its advantages in addition to present demanding situations and boundaries. it really is defined how, because its advent for the remedy of exudative age-related macular degeneration in 2006, anti-angiogenic treatment has revolutionized the way we deal with a number of ocular illnesses. the entire authors are confirmed specialists of their respective fields who proportion their wide wisdom and medical event with the reader. This booklet is either a useful advent to anti-angiogenic treatment in ophthalmology and a daily significant other for all ophthalmologists seeing sufferers with the most established retinal diseases.
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Extra resources for Anti-Angiogenic Therapy in Ophthalmology
2013). The mean gain in VA reported with regular 4-weekly regimes across phase III clinical trials has varied between 7 and 11 Early Treatment Diabetic Retinopathy Study (EDTRS) letters (Lanzetta et al. 2013). Long-term follow-up of patients treated with RBZ was reported in the SEVEN-UP study (Rofagha et al. 2013), a multicenter cohort study which reviewed 65 study eyes, which had successfully completed ANCHOR or MARINA protocols within the RBZ arms (which received 4-weekly RBZ for 2 years) followed by completion of the HORIZON study protocol (Singer et al.
2012;119(7):1388–98. 053. S0161-6420(12)00321-1 [pii]. Martinez-Castellanos MA, Schwartz S, Hernandez-Rojas ML, Kon-Jara VA, Garcia-Aguirre G, Guerrero-Naranjo JL, Chan RV, Quiroz-Mercado H. Long-term effect of antiangiogenic therapy for retinopathy of prematurity up to 5 years of follow-up. Retina. 2013;33(2):329–38. 0b013e318275394a. Massin P, Bandello F, Garweg JG, Hansen LL, Harding SP, Larsen M, Mitchell P, Sharp D, Wolf-Schnurrbusch UE, Gekkieva M, Weichselberger A, Wolf S. Safety and efficacy of ranibizumab in diabetic macular edema (RESOLVE Study): a 12-month, randomized, controlled, double-masked, multicenter phase II study.
3 mg Clinical trial EXCITE (Schmidt-Erfurth et al. 44) (n = 230) NR NR NR NR NR NR Clinical trial Clinical trial Clinical trial Clinical Practice Clinical Practice ABC-Trial (Tufail et al. 2010) Sacu et al. (2009) Kruger Falk et al. (2013) Rasmussen et al. 5 mg PrONTO (Fung et al. 2007; Lalwani et al. 3 mg (n = 29). Data pooled Clinical practice follow-up of a Clinical trial sample SEVEN-UP (Rofagha et al. 5 (Variable follow-up time. 7 (Range 1–35) NR NR NR No. 63) No. 8) (n = 65) VA at >2 years (Time point) (n at given time point) Clinical Practice Clinical Practice Clinical Practice Marques et al.
Anti-Angiogenic Therapy in Ophthalmology by Andreas Stahl