By Manfred Zierhut, Hans-Georg Rammensee, Wayne Streilein
In recent times the significance of antigen-presenting cells and their impact at the eyes has been elucidated. we've got discovered that just about each constitution of the attention harbors those cells, but they fluctuate of their actions and therefore within the ways that they defend opposed to - or perform - illnesses of the attention. Antigen-Presenting Cells and the attention summarizes present wisdom approximately ACPs in most cases, and their function within the eye, specifically.
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Extra info for Antigen-presenting cells and the eye
F4/80 protein is a molecule that has long been associated as a marker of tissue macrophages. The F4/80 molecule was identified over twenty years ago as a 160-kDa molecule expressed on the plasma membrane of restricted subsets of mouse macrophages, monocytes, and dendritic cells found throughout the lymphoid system and elsewhere in the body (36). The expression of its F4/80 molecule is known to fluctuate in response to BCG infection or IFN-γ (37). Additionally, the fact that it is known that F4/80 expression on activated Langerhans cells and other migrating APCs decreases, suggests a role for the molecule in cellular adhesion events (38).
31) show that DEC-205+ liver DCs are poor T-cell stimulators and induce T cells that produce the anti-inflammatory cytokine IL-10. In addition, a subset of DEC-205+/CD8+ DCs has been identified in mouse spleen, that is able to curb proliferation of CD8+ T cells in vitro by inducing TH2-like cytokines (32). So, even if the functional aspects of DEC-205–mediated antigen presentation to the tolerance induction remains elusive, DEC-205 expression might serve as a suitable marker to characterize tolerogenic DCs (33,34).
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Antigen-presenting cells and the eye by Manfred Zierhut, Hans-Georg Rammensee, Wayne Streilein